Regulatory challenges are commonplace for companies trying to innovate in the marketplace, and entire industries are being reshaped by companies focusing in the sharing economy; new financial technologies, such as peer-to-peer lending, robo-advisors, blockchain, bitcoin, and any form of money and credit transmission; drones; medical technology; and a myriad other markets. Privacy regulations emanating from Europe and several other geographies, often demanding local data hosting, add another layer of complexity, as do domestic regulations governing personally identifiable information. And, the pervasive concern over encryption and data privacy implicates questions that reach to the core of our nation’s value system. This panel will address this broad array of challenges and will seek to draw broader themes while suggesting constructive approaches for engagement between innovative companies and various domestic and foreign regulatory regimes.